Successful therapeutic approaches for the treatment of psoriasis

Abstract

Introduction: Psoriasis is defined as a chronic inflammatory skin disease that has a prevalence in the world population ranging from 1 to 5%. Objective: The study aims to raise studies in the literature that present successful therapies for the treatment of psoriasis. Methods: This is an integrative literature review. The research was carried out through a search for studies in the databases: Latin American and Caribbean Literature in Health Sciences, LILACS, via VHL and MedLine via Pubmed. Inclusion criteria were: articles available in full and freely accessible, in Portuguese, English and Spanish, published between January 2014 and December 2021. Exclusion criteria were duplicate, incomplete studies, abstracts, reviews, debates, published articles in event annals, unavailable in full or that did not present a clear proposal were excluded during the analyses, as well as literature reviews. Results: From October to December 2021, 09 articles were selected for final analysis. The certolizumab-treated and etanercept-treated groups had comparable safety profiles through week 12 and fewer certolizumab-treated patients than etanercept-treated patients discontinued due to adverse events. In general, none of the authors considered the lifestyle and eating habits of the study participants in the analysis. Conclusion: It was evidenced that for vulgar psoriasis the use of microinfusion in the skin of Cyclosporine and Methotrexate showed tolerability, absence of adverse effects and fast response. Tripterygium wilfordii Hook F may be an effective and safe treatment in patients with moderate to severe psoriasis vulgaris, especially for patients who have contraindications to other therapies.